KMID : 0363020050350040961
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Journal of Korean Academy of Periodontology 2005 Volume.35 No. 4 p.961 ~ p.974
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The quantitative analysis by digital subtraction radiography on the effect of Enamel Matrix Protein and Platelet-Rich Plasma, combined with Xenograft in the treatment of intrabony defect in humans
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ÀÓ¼ººó/Á¤ÁøÇü/È«±â¼®
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Abstract
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Various biological approaches to the promotion of periodontal regeneration have been used.
These can be divided into the use of growth and differentiation factors, application of
extracellular matrix proteins and attachment factors and use of mediators of bone metabolism.
The purpose of this study was to evaluate the effect of enamel matrix protein and
platelet-rich plasma on the treatment of intrabony defect, with bovine-derived bone powder in
humans by digital subtraction radiography. 12 teeth(experimental I group) were treated with
enamel matrix protein combined with bovine-derived bone powder and 12 teeth(experimental II
group) were treated with platelet-rich plasma combined with bovine-derived bone powder. The
change of bone density was assessed by digital subtraction radiography in this study. The
change of mineral content was assessed in the method that two radiographs were put into
computer program to be overlapped and the previous image was subtracted by the later one.
Both groups were statistically analyzed by Wilcoxon signed Ranks Test and Mann-whitney
Test using SPSS program for windows(5% significance level).
The results were as follows:
1. The radiolucency in 3 months after surgery was significantly increased than 1 month
after surgery in both groups(experimental I and II groups)(p<0.05).
2. The radiopacity in 6 months after surgery was significantly increased than 3 months after
surgery in both groups(experimental I and II groups)(p<0.05).
3. In experimental I group, there was no significant difference between 1 month and 6
months after surgery.
4. In experimental II group, the radiopacity in 6 months after surgery was significantly
increased than 1 month after surgery(p<0.05).
5. There was no significant difference between experimental I and II group at 1 month and
3 months after surgery, but the radiopacity in experimental II group was significantly
increased at 6 months after surgery(p<0.05).
In conclusion, platelet-rich plasma can enhance bone density than enamel matrix protein
until 6 months after surgery.2)
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KEYWORD
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digital subtraction radiography, Enamel Matrix Protein, Platelet-Rich Plasma, Xenograft
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